A current review of dose-escalated radiotherapy in locally advanced non-small cell lung cancer

A current review of dose-escalated radiotherapy in locally advanced non-small cell lung cancer

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The mainstay therapy for locally advanced non-small cell lung cancer is concurrent 1994-2004 chemoradiotherapy.Loco-regional recurrence constitutes the predominant failure patterns.Previous studies confirmed the relationship between increased biological equivalent doses and improved overall survival.However, the large randomized phase III study, RTOG 0617, failed to demonstrate the benefit Skin Toner of dose-escalation to 74 Gy compared with 60 Gy by simply increasing fraction numbers.